Psychedelics Reduce Depressive Symptoms by Helping Individuals Process Emotions, Yet Another Study Finds

Psychedelics Reduce Depressive Symptoms by Helping Individuals Process Emotions, Yet Another Study Finds

New research provides preliminary evidence that psychedelic drugs can improve mental health by making individuals more accepting of distressing experiences. The study, published in Frontiers in Psychiatry, adds to a growing body of literature that indicates using substances like psilocybin can result in sustain improvements in depressive symptoms.

“Psychedelic therapy has shown promise as a novel treatment for a range of mental health concerns, including major depressive disorder, distress associated with a life-threatening illness, and substance use disorders,” said study author Richard Zeifman, a PhD student at Ryerson University and research intern at the Centre for Psychedelic Research at Imperial College London.

“In contrast with the traditional pharmacological interventions, the effects of psychedelic therapy appear to last months and even years after treatment has ended. Understanding how psychedelic therapy leads to long-lasting mental health improvements across a range of conditions is not yet fully understood but is important for enhancing and delivering psychedelic therapy to individuals that may benefit from it.”

 

The researchers were particularly interested in the transdiagnostic construct known as experiential avoidance, meaning the tendency to avoid unpleasant thoughts and feelings. People who score high on a measure of experiential avoidance agree with statements such as “I would give up a lot not to feel bad” and “I go out of my way to avoid uncomfortable situations.”

For their study, the researchers used online advertisements to recruit a sample of 104 individuals who planned to use a psychedelic substance and a second sample of 254 individuals who planned to attend psychedelic ceremonies. Both samples completed measures of depression severity, experiential avoidance, and suicidal ideation one week before and 4 weeks after using their psychedelic substance of choice.

Zeifman and his colleagues found that the use of psychedelics in both ceremonial and non-ceremonial settings was associated with decreases in experiential avoidance, which in turn was associated with decreases in depression severity and suicidal ideation 4-weeks after psychedelic use. Psilocybin/magic mushrooms, LSD, and ayahuasca were the most commonly used substances in the study.

“Our findings suggest that one of the reasons that psychedelic therapy has positive therapeutic effects is that it helps individuals to be less avoidant and more accepting of their emotions, thoughts, and memories (even though such experiences may be distressing in the short-term),” Zeifman told PsyPost.

“More broadly, our results provide further support for the negative mental health effects associated with avoidance. This can be summed up with a saying that is often used in the context of psychedelic therapy, that ‘The only way out is through.’”

But the study — like all research — includes some caveats.

“There were important limitations to our study, including that our study was not conducted in the context of a controlled clinical trial or within a clinical sample. Accordingly, we are currently conducting research where we are comparing the effects of psychedelic therapy versus a traditional antidepressant (called escitalopram) on experiential avoidance. This research will help to further examine the possibility that psychedelic therapy leads to change through different mechanisms than do traditional pharmacological interventions for depression,” Zeifman said.

The study, “Post-Psychedelic Reductions in Experiential Avoidance Are Associated With Decreases in Depression Severity and Suicidal Ideation“, was authored by Richard J. Zeifman, Anne C. Wagner, Ros Watts, Hannes Kettner, Lea J. Mertens, and Robin L. Carhart-Harris.

Animals Eat Psychoactive Plants for an Intentional Break from Reality

Animals Eat Psychoactive Plants for an Intentional Break from Reality

The United Nations says Animals Eat Psychoactive Plants the drug war’s rationale is to build “a drug-free world — we can do it!” U.S. government officials agree, stressing that “there is no such thing as recreational drug use.” So this isn’t a war to stop addiction, like that in my family, or teenage drug use. It is a war to stop drug use among all humans, everywhere. All these prohibited chemicals need to be rounded up and removed from the earth. That is what we are fighting for.

I began to see this goal differently after I learned the story of the drunk elephants, the stoned water buffalo, and the grieving mongoose. They were all taught to me by a remarkable scientist in Los Angeles named Professor Ronald K. Siegel.

***
The tropical storm in Hawaii had reduced the mongoose’s home to a mess of mud, and lying there, amid the dirt and the water, was the mongoose’s mate — dead. Professor Siegel, a silver-haired official adviser to two U.S. presidents and to the World Health Organization, was watching this scene. The mongoose found the corpse, and it made a decision: it wanted to get out of its mind.

Two months before, the professor had planted a powerful hallucinogen called silver morning glory in the pen. The mongooses had all tried it, but they didn’t seem to like it: they stumbled around disoriented for a few hours and had stayed away from it ever since. But not now. Stricken with grief, the mongoose began to chew. Before long, it had tuned in and dropped out.
It turns out this wasn’t a freak occurrence in the animal kingdom. It is routine. As a young scientific researcher, Siegel had been confidently toldby his supervisor that humans were the only species that seek out drugs to use for their own pleasure. But Siegel had seen cats lunging at catnip — which, he knew, contains chemicals that mimic the pheromones in a male tomcat’s pee —so, he wondered, could his supervisor really be right? Given the number of species in the world, aren’t there others who want to get high, or stoned, or drunk?

This question set him on a path that would take twenty-five years of his life, studying the drug-taking habits of animals from the mongooses of Hawaii to the elephants of South Africa to the grasshoppers of Soviet-occupied Czechoslovakia. It was such an implausible mission that in one marijuana field in Hawaii, he was taken hostage by the local drug dealers, because when he told them he was there to see what happened when mongooses ate marijuana, they thought it was the worst police cover story they had ever heard.

What Ronald K. Siegel discovered seems strange at first. He explains in his book Intoxication:

After sampling the numbing nectar of certain orchids, bees drop to the ground in a temporary stupor, then weave back for more. Birds gorge themselves on inebriating berries, then fly with reckless abandon. Cats eagerly sniff aromatic “pleasure” plants, then play with imaginary objects. Cows that browse special range weeds will twitch, shake, and stumble back to the plants for more. Elephants purposely get drunk off fermented fruits. Snacks of “magic mushrooms” cause monkeys to sit with their heads in their hands in a posture reminiscent of Rodin’s Thinker. The pursuit of intoxication by animals seems as purposeless as it is passionate. Many animals engage these plants, or their manufactured allies, despite the danger of toxic or poisonous effects.

Noah’s Ark, he found, would have looked a lot like London on a Saturday night. “In every country, in almost every class of animal,” Siegel explains, “I found examples of not only the accidental but the intentional use of drugs.” In West Bengal, a group of 150 elephants smashed their way into a warehouse and drank a massive amount of moonshine. They got so drunk they went on a rampage and killed five people, as well as demolishing seven concrete buildings. If you give hash to male mice, they become horny and seek out females — but then they find “they can barely crawl over the females, let alone mount them,” so after a little while they yawn and start licking their own penises.

Excerpted from Johann Hari’s Chasing the Scream: The First and Last Days of the War on Drugs. Available from Amazon.
In Vietnam, the water buffalo have always shunned the local opium plants. They don’t like them. But when the American bombs started to fall all around them during the war, the buffalo left their normal grazing grounds, broke into the opium fields, and began to chew. They would then look a little dizzy and dulled. When they were traumatized, it seems, they wanted — like the mongoose, like us — to escape from their thoughts.

***
I kept returning to the UN pledge to build a drug-free world. There was one fact, above all others, that I kept placing next to it in my mind. It is a fact that seems at first glance both obvious and instinctively wrong. Only 10 percent of drug users have a problem with their substance. Some 90 percent of people who use a drug—the overwhelming majority—are not harmed by it. This figure comes not from a pro-legalization group, but from the United Nations Office on Drug Control, the global coordinator of the drug war. Even William Bennett, the most aggressive drug czar in U.S. history, admits: “Non-addicted users still comprise the vast bulk of our drug-involved population.”

This is hard to dispute, yet hard to absorb. If we think about people we know, it seems about right—only a small minority of my friends who drink become alcoholics, and only a small minority of the people I know who use drugs on a night out have become addicts.

But if you think about how we are trained to think about drugs, this seems instinctively wrong, even dangerous. All we see in the public sphere are the casualties. The unharmed 90 percent use in private, and we rarely hear about it or see it. The damaged 10 percent, by contrast, are the only people we ever see using drugs out on the streets. The result is that the harmed 10 percent make up 100 percent of the official picture. It is as if our only picture of drinkers were a homeless person lying in a gutter necking neat gin. This impression is then reinforced with the full power of the state. For example, in 1995, the World Health Organization (WHO) conducted a massive scientific study of cocaine and its effects. They discovered that “experimental and occasional use are by far the most common types of use, and compulsive/dysfunctional [use] is far less common.” The U.S. government threatened to cut off funding to the WHO unless they suppressed the report. It has never been published; we know what it says only because it was leaked.

As I write this, I feel uncomfortable. The 10 percent who are harmed are most vivid to me—they are some of the people I love most. And there is another, more complex reason why I feel awkward writing about this. For anybody who suspects that we need to reform the drug laws, there is an easier argument to make, and a harder argument to make.

The easier argument is to say that we all agree drugs are bad — it’s just that drug prohibition is even worse. I have made this argument in debates in the past. Prohibition, I said, doesn’t stop the problem, it simply piles another series of disasters onto the already-existing disaster of drug use. In this argument, we are all antidrug. The only difference is between prohibitionists who believe the tragedy of drug use can be dealt with by more jail cells in California and more military jeeps on the streets of Juárez, and the reformers who believe the tragedy of drug use can be dealt by moving those funds to educate kids and treat addicts.

There’s a lot of truth in this argument. It is where my instincts lie. But — as I try to think through this problem — I have to admit it is only a partial truth.

Here, I think, is the harder, more honest argument. Some drug use causes horrible harm, as I know very well, but the overwhelming majority of people who use prohibited drugs do it because they get something good out of it — a fun night out dancing, the ability to meet a deadline, the chance of a good night’s sleep, or insights into parts of their brain they couldn’t get to on their own. For them, it’s a positive experience, one that makes their lives better. That’s why so many of them choose it. They are not suffering from false consciousness, or hubris. They don’t need to be stopped from harming themselves, because they are not harming themselves. As the American writer Nick Gillespie puts it: “Far from our drugs controlling us, by and large we control our drugs; as with alcohol, the primary motivation is to enjoy ourselves, not to destroy ourselves . . . There is such a thing as responsible drug use, and it is the norm, not the exception.”

So, although it is against my instincts, I realized I couldn’t give an honest account of drug use in this book if I talked only about the harm it causes. If I’m serious about this subject, I also have to look at how drug use is deeply widespread — and mostly positive.

***
Professor Siegel’s story of buzzing cows and tripping bees is, he believes, a story about us. We are an animal species. As soon as plants began to be eaten by animals for the first time — way back in prehistory, before the first human took his first steps — the plants evolved chemicals to protect themselves from being devoured and destroyed. But these chemicals could, it soon turned out, produce strange effects. In some cases, instead of poisoning the plant’s predators, they — quite by accident — altered their consciousness. This is when the pleasure of getting wasted enters history. All human children experience the impulse early on: it’s why when you were little you would spin around and around, or hold your breath to get a head rush. You knew it would make you sick, but your desire to change your consciousness a little — to experience a new and unfamiliar rush — outweighed your aversion to nausea.

There has never been a society in which humans didn’t serially seek out these sensations. High in the Andes in 2000 b.c., they were making pipes through which they smoked hallucinogenic herbs. Ovid said drug-induced ecstasy was a divine gift. The Chinese were cultivating opium by a.d. 700. Hallucinogens and chemicals caused by burning cannabis were found in clay pipe fragments from William Shakespeare’s house. George Washington insisted that American soldiers be given whiskey every day as part of their rations.

“The ubiquity of drug use is so striking,” the physician Andrew Weil concludes, that “it must represent a basic human appetite.” Professor Siegel claims the desire to alter our consciousness is “the fourth drive” in all human minds, alongside the desire to eat, drink, and have sex—and it is “biologically inevitable.” It provides us with moments of release and relief.

***
Thousands of people were streaming in to a ten-day festival in September where they were planning — after a long burst of hard work — to find some chemical release, relaxation, and revelry. They found drugs passed around the crowd freely, to anybody who wanted them. Everyone who took them soon felt an incredible surge of ecstasy. Then came the vivid, startling hallucinations. You suddenly felt, as one user put it, something that was “new, astonishing, irrational to rational cognition.”

Some people came back every year because they loved this experience so much. As the crowd thronged and yelled and sang, it became clear it was an extraordinary mix of human beings. There were farmers who had just finished their harvest, and some of the biggest celebrities around. Their names—over the years—included Sophocles, Aristotle, Plato, and Cicero.

The annual ritual in the Temple at Eleusis, eighteen kilometers northwest of Athens, was a drug party on a vast scale. It happened every year for two thousand years, and anybody who spoke the Greek language was free to come. Harry Anslinger said that drug use represents “nothing less than an assault on the foundations of Western civilization,” but here, at the actual foundations of Western civilization, drug use was ritualized and celebrated.

I first discovered this fact by reading the work of the British critic Stuart Walton in a brilliant book called Out of It, and then I followed up with some of his sources, which include the work of Professor R. Gordon Wasson, Professor Carl Ruck, and other writers.

Everyone who attended the Eleusinian mysteries was sworn to secrecy about what happened there, so our knowledge is based on scraps of information that were recorded in its final years, as it was being suppressed. We do know that a special cup containing a mysterious chemical brew of hallucinogens would be passed around the crowd, and a scientific study years later seemed to prove it contained a molecular relative of LSD taken from a fungus that infested cereal crops and caused hallucinations. The chemical contents of this cup were carefully guarded for the rest of the year. The drugs were legal – indeed, this drug use was arranged by public officials – and regulated. You could use them, but only in the designated temple for those ten days. One day in 415 b.c., a partygoing general named Alcibiades smuggled some of the mystery drug out and took it home for his friends to use at their parties. Walton writes: “Caught in possession with intent to supply, he was the first drug criminal.”

But while it was a crime away from the Temple and other confined spaces, it was a glory within it. According to these accounts, it was Studio 54 spliced with St. Peter’s Basilica – revelry with religious reverence.

They believed the drugs brought them closer to the gods, or even made it possible for them to become gods themselves. The classicist Dr. D.C.A.

Hillman wrote that the “founding fathers” of the Western world

were drug users, plain and simple: they grew the stuff, they sold the stuff, and more important, they used the stuff . . . The ancient world didn’t have a Nancy Reagan, it didn’t wage a billion-dollar drug war, it didn’t imprison people who used drugs, and it didn’t embrace sobriety as a virtue. It indulged . . . and from this world in which drugs were a universally accepted part of life sprang art, literature, science, and philosophy . . . The West would not have survived without these so-called junkies and drug dealers.

There was some political grumbling for years that women were behaving too freely during their trances, but this annual festival ended only when the drug party crashed into Christianity. The early Christians wanted there to be one route to ecstasy, and one route only – through prayer to their God. You shouldn’t feel anything that profound or pleasurable except in our ceremonies at our churches. The first tugs towards prohibition were about power, and purity of belief. If you are going to have one God and one Church, you need to stop experiences that make people feel that they can approach God on their own. It is no coincidence that when new drugs come along, humans often use religious words to describe them, like ecstasy. They are often competing for the same brain space – our sense of awe and joy.

So when the emperor Constantine converted to Christianity and brought the Empire with him, the rituals at the Temple at Eleusis were doomed. They were branded a cult and shut down by force. The new Christianity would promote wine only in tiny sips. Intoxication had to be sparing. This “forcible repression by Christianity,” Walton explains, “represents the beginning of systematic repression of the intoxication impulse in the lives of Western citizens.”

Yet in every generation after, some humans would try to rebuild their own Temple at Eleusis—in their own minds, and wherever they could clear a space free of local Anslingers.

Harry Anslinger, it turns out, represented a trend running right back to the ancient world.

When Sigmund Freud first suggested that everybody has elaborate sexual fantasies, that it is as natural as breathing, he was dismissed as a pervert and lunatic. People wanted to believe that sexual fantasy was something that happened in other people – filthy people, dirty people. They took the parts of their subconscious that generated these wet dreams and daydreams and projected them onto somebody else, the depraved people Over There, who had to be stopped. Stuart Walton and the philosopher Terence McKenna both write that we are at this stage with our

equally universal desire to seek out altered mental states. McKenna explains: “We are discovering that human beings are creatures of chemical habit with the same horrified disbelief as when the Victorians discovered that humans are creatures of sexual fantasy and obsession.”

Just as we are rescuing the sex drive from our subconscious and from shame, so we need to take the intoxication drive out into the open where it can breathe. Stuart Walton calls for a whole new field of human knowledge called “intoxicology.” He writes: “Intoxication plays, or has played, a part in the lives of virtually everybody who has ever lived . . . To seek to deny it is not only futile; it is a dereliction of an entirely constitutive part of who we are.”

***
After twenty-five years of watching stoned mice, drunken elephants, and tripping mongooses, Ronald K. Siegel tells me he suspects he has learned something about this. “We’re not so different from the other animal life-forms on this planet,” he says.

When he sees people raging against all drug use, he is puzzled. “They’re denying their own chemistry,” he says. “The brain produces endorphins. When does it produce endorphins? In stress, and in pain. What are endorphins? They are morphine-like compounds. It’s a natural occurrence in the brain that makes them feel good . . . People feel euphoric sometimes. These are chemical changes – the same kind of chemical changes, with the same molecular structures, that these plants [we use to make our drugs] are producing . . . We’re all producing the same stuff.”

Indeed, he continues, “the experience you have in orgasm is partially chemical – it’s a drug. So people deny they want this? Come on! . . . It’s fun. It’s enjoyable. And it’s chemical. That’s intoxication.” He seems for a moment to think back over all the animals guzzling drugs he has watched over all these years. “I don’t see,” he says, “any difference in where the chemical came from.”

This is in us. It is in our brains. It is part of who we are.

via BoingBoing
ABOUT THE AUTHOR

Johann Hari is a British journalist who has written for the New York Times, Le Monde, the Los Angeles Times, the Independent, the Guardian, Slate, the New Republic, and the Nation. He has reported from many countries, from the Congo to Venezuela. He was twice named Newspaper Journalist of the Year by Amnesty International UK, awarded the Martha Gellhorn Prize for turning political writing into an art, and later named Journalist of the Year by Stonewall. He can be followed on Twitter: @johannhari101

Drugs and the Meaning of Life

Drugs and the Meaning of Life

Everything we do is for the purpose of altering consciousness. We form friendships so that we can feel certain emotions, like love, and avoid others, like loneliness. We eat specific foods to enjoy their fleeting presence on our tongues. We read for the pleasure of thinking another person’s thoughts. Every waking moment—and even in our dreams—we struggle to direct the flow of sensation, emotion, and cognition toward states of consciousness that we value.

Drugs are another means toward this end. Some are illegal; some are stigmatized; some are dangerous—though, perversely, these sets only partially intersect. There are drugs of extraordinary power and utility, like psilocybin (the active compound in “magic mushrooms”) and lysergic acid diethylamide (LSD), which pose no apparent risk of addiction and are physically well-tolerated, and yet one can still be sent to prison for their use—while drugs like tobacco and alcohol, which have ruined countless lives, are enjoyed ad libitum in almost every society on earth. There are other points on this continuum—3,4-methylene-dioxy-N-methylamphetamine (MDMA or “Ecstasy”) has remarkable therapeutic potential, but it is also susceptible to abuse, and it appears to be neurotoxic.[1]

One of the great responsibilities we have as a society is to educate ourselves, along with the next generation, about which substances are worth ingesting, and for what purpose, and which are not. The problem, however, is that we refer to all biologically active compounds by a single term—“drugs”—and this makes it nearly impossible to have an intelligent discussion about the psychological, medical, ethical, and legal issues surrounding their use. The poverty of our language has been only slightly eased by the introduction of terms like “psychedelics” to differentiate certain visionary compounds, which can produce extraordinary states of ecstasy and insight, from “narcotics” and other classic agents of stupefaction and abuse.

Drug abuse and addiction are real problems, of course—the remedy for which is education and medical treatment, not incarceration. In fact, the worst drugs of abuse in the United States now appear to be prescription painkillers, like oxycodone. Should these medicines be made illegal? Of course not. People need to be informed about them, and addicts need treatment. And all drugs—including alcohol, cigarettes, and aspirin—must be kept out of the hands of children.

I discuss issues of drug policy in some detail in my first book, The End of Faith (pp. 158-164), and my thinking on the subject has not changed. The “war on drugs” has been well lost, and should never have been waged. While it isn’t explicitly protected by the U.S. Constitution, I can think of no political right more fundamental than the right to peacefully steward the contents of one’s own consciousness. The fact that we pointlessly ruin the lives of nonviolent drug users by incarcerating them, at enormous expense, constitutes one of the great moral failures of our time. (And the fact that we make room for them in our prisons by paroling murderers and rapists makes one wonder whether civilization isn’t simply doomed.)

I have a daughter who will one day take drugs. Of course, I will do everything in my power to see that she chooses her drugs wisely, but a life without drugs is neither foreseeable, nor, I think, desirable. Someday, I hope she enjoys a morning cup of tea or coffee as much as I do. If my daughter drinks alcohol as an adult, as she probably will, I will encourage her to do it safely. If she chooses to smoke marijuana, I will urge moderation.[2]  Tobacco should be shunned, of course, and I will do everything within the bounds of decent parenting to steer her away from it. Needless to say, if I knew my daughter would eventually develop a fondness for methamphetamine or crack cocaine, I might never sleep again. But if she does not try a psychedelic like psilocybin or LSD at least once in her adult life, I will worry that she may have missed one of the most important rites of passage a human being can experience.

This is not to say that everyone should take psychedelics. As I will make clear below, these drugs pose certain dangers. Undoubtedly, there are people who cannot afford to give the anchor of sanity even the slightest tug. It has been many years since I have taken psychedelics, in fact, and my abstinence is born of a healthy respect for the risks involved. However, there was a period in my early 20’s when I found drugs like psilocybin and LSD to be indispensable tools of insight, and some of the most important hours of my life were spent under their influence. I think it quite possible that I might never have discovered that there was an inner landscape of mind worth exploring without having first pressed this pharmacological advantage.

While human beings have ingested plant-based psychedelics for millennia, scientific research on these compounds did not begin until the 1950’s. By 1965, a thousand studies had been published, primarily on psilocybin and LSD, many of which attested to the usefulness of psychedelics in the treatment of clinical depression, obsessive compulsive disorder (OCD), alcohol addiction, and the pain and anxiety associated with terminal cancer. Within a few years, however, this entire field of research was abolished in an effort to stem the spread of these drugs among the general public. After a hiatus that lasted an entire generation, scientific research on the pharmacology and therapeutic value of psychedelics has quietly resumed.

The psychedelics include chemicals like psilocybin, LSD, DMT, and mescaline—all of which powerfully alter cognition, perception, and mood. Most seem to exert their influence through the serotonin system in the brain, primarily by binding to 5-HT2A receptors (though several have affinity for other receptors as well), leading to increased neuronal activity in prefrontal cortex (PFC). While the PFC in turn modulates subcortical dopamine production, the effect of psychedelics appears to take place largely outside dopamine pathways (which might explain why these drugs are not habit forming).

The mere existence of psychedelics would seem to establish the material basis of mental and spiritual life beyond any doubt—for the introduction of these substances into the brain is the obvious cause of any numinous apocalypse that follows. It is possible, however, if not actually plausible, to seize this datum from the other end and argue, and Aldous Huxley did in his classic essay, The Doors of Perception, that the primary function of the brain could be eliminative: its purpose could be to prevent some vast, transpersonal dimension of mind from flooding consciousness, thereby allowing apes like ourselves to make their way in the world without being dazzled at every step by visionary phenomena irrelevant to their survival. Huxley thought that if the brain were a kind of “reducing valve” for “Mind at Large,” this would explain the efficacy of psychedelics: They could simply be a material means of opening the tap.

Unfortunately, Huxley was operating under the erroneous assumption that psychedelics decrease brain activity. However, modern techniques of neuroimaging have shown that these drugs tend to increase activity in many regions of the cortex (and in subcortical structures as well) [Note 1/24/12: a recent study on psilocybin actually lends some support to Huxley’s view.—SH] . Still, the action of these drugs does not rule out dualism, or the existence of realms of mind beyond the brain—but then nothing does. This is one of the problems with views of this kind: They appear to be unfalsifiable.[3]

Of course, the brain does filter an extraordinary amount of information from consciousness. And, like many who have taken these drugs, I can attest that psychedelics certainly throw open the gates. Needless to say, positing the existence of a “Mind at Large” is more tempting in some states of consciousness than in others. And the question of which view of reality we should privilege is, at times, worth considering. But these drugs can also produce mental states that are best viewed in clinical terms as forms of psychosis. As a general matter, I believe we should be very slow to make conclusions about the nature of the cosmos based upon inner experience — no matter how profound these experiences seem.

However, there is no question that the mind is vaster and more fluid than our ordinary, waking consciousness suggests. Consequently, it is impossible to communicate the profundity (or seeming profundity) of psychedelic states to those who have never had such experiences themselves. It is, in fact, difficult to remind oneself of the power of these states once they have passed.

Many people wonder about the difference between meditation (and other contemplative practices) and psychedelics. Are these drugs a form of cheating, or are they the one, indispensable vehicle for authentic awakening? They are neither. Many people don’t realize that all psychoactive drugs modulate the existing neurochemistry of the brain—either by mimicking specific neurotransmitters or by causing the neurotransmitters themselves to be more active. There is nothing that one can experience on a drug that is not, at some level, an expression of the brain’s potential. Hence, whatever one has experienced after ingesting a drug like LSD is likely to have been experienced, by someone, somewhere, without it.

However, it cannot be denied that psychedelics are a uniquely potent means of altering consciousness. If a person learns to meditate, pray, chant, do yoga, etc., there is no guarantee that anything will happen. Depending on his aptitude, interest, etc., boredom could be the only reward for his efforts. If, however, a person ingests 100 micrograms of LSD, what will happen next will depend on a variety of factors, but there is absolutely no question that something will happen. And boredom is simply not in the cards. Within the hour, the significance of his existence will bear down upon our hero like an avalanche. As Terence McKenna[4]  never tired of pointing out, this guarantee of profound effect, for better or worse, is what separates psychedelics from every other method of spiritual inquiry. It is, however, a difference that brings with it certain liabilities.

Ingesting a powerful dose of a psychedelic drug is like strapping oneself to a rocket without a guidance system. One might wind up somewhere worth going—and, depending on the compound and one’s “set and setting,” certain trajectories are more likely than others. But however methodically one prepares for the voyage, one can still be hurled into states of mind so painful and confusing as to be indistinguishable from psychosis. Hence, the terms “psychotomimetic” and “psychotogenic” that are occasionally applied to these drugs.

I have visited both extremes on the psychedelic continuum. The positive experiences were more sublime than I could have ever imagined or than I can now faithfully recall. These chemicals disclose layers of beauty that art is powerless to capture and for which the beauty of Nature herself is a mere simulacrum. It is one thing to be awestruck by the sight of a giant redwood and to be amazed at the details of its history and underlying biology. It is quite another to spend an apparent eternity in egoless communion with it. Positive psychedelic experiences often reveal how wondrously at ease in the universe a human being can be—and for most of us, normal waking consciousness does not offer so much as a glimmer of these deeper possibilities.

People generally come away from such experiences with a sense that our conventional states of consciousness obscure and truncate insights and emotions that are sacred. If the patriarchs and matriarchs of the world’s religions experienced such states of mind, many of their claims about the nature of reality can make subjective sense. The beautific vision does not tell you anything about the birth of the cosmos—but it does reveal how utterly transfigured a mind can be by a full collision with the present moment.

But as the peaks are high, the valleys are deep. My “bad trips” were, without question, the most harrowing hours I have ever suffered—and they make the notion of hell, as a metaphor if not a destination, seem perfectly apt. If nothing else, these excruciating experiences can become a source of compassion. I think it would be impossible to have any sense of what it is like to suffer from mental illness without having briefly touched its shores.

At both ends of the continuum time dilates in ways that cannot be described—apart from saying that these experiences can seem eternal. I have had sessions, both positive and negative, in which any knowledge that I had ingested a drug had been extinguished, and all memories of my past along with it. Full immersion in the present moment, to this degree, is synonymous with the feeling that one has always been, and will always be, in precisely this condition. Depending on the character of one’s experience at that point, notions of salvation and damnation do not seem hyperbolic. In my experience, Blake’s line about beholding “eternity in an hour” neither promises, nor threatens, too much.

In the beginning, my experiences with psilocybin and LSD were so positive that I could not believe a bad trip was possible. Notions of “set and setting,” admittedly vague, seemed sufficient to account for this. My mental set was exactly as it needed to be—I was a spiritually serious investigator of my own mind—and my setting was generally one of either natural beauty or secure solitude.

I cannot account for why my adventures with psychedelics were uniformly pleasant until they weren’t—but when the doors to hell finally opened, they appear to have been left permanently ajar. Thereafter, whether or not a trip was good in the aggregate, it generally entailed some harrowing detour on the path to sublimity. Have you ever traveled, beyond all mere metaphors, to the Mountain of Shame and stayed for a thousand years? I do not recommend it.

image

(Pokhara, Nepal)

On my first trip to Nepal, I took a rowboat out on Phewa Lake in Pokhara, which offers a stunning view of the Annapurna range. It was early morning, and I was alone. As the sun rose over the water, I ingested 400 micrograms of LSD. I was 20 years old and had taken the drug at least ten times previously. What could go wrong?

Everything, as it turns out. Well, not everything—I didn’t drown. And I have a vague memory of drifting ashore and of being surrounded by a group of Nepali soldiers. After watching me for a while, as I ogled them over the gunwale like a lunatic, they seemed on the verge of deciding what to do with me. Some polite words of Esperanto, and a few, mad oar strokes, and I was off shore and into oblivion. So I suppose that could have ended differently.

But soon there was no lake or mountains or boat—and if I had fallen into the water I am pretty sure there would have been no one to swim. For the next several hours my mind became the perfect instrument of self-torture. All that remained was a continuous shattering and terror for which I have no words.

These encounters take something out of you. Even if drugs like LSD are biologically safe, the potential for extremely unpleasant and destabilizing experiences presents its own risks. I believe I was positively affected for weeks and months by my good trips, and negatively affected by the bad ones. Given these roulette-like odds, one can only recommend these experiences with caution.

While meditation can open the mind to a similar range of conscious states, they are reached far less haphazardly. If LSD is like being strapped to rocket, learning to meditate is like gently raising a sail. Yes, it is possible, even with guidance, to wind up someplace terrifying—and there are people who probably shouldn’t spend long periods in intensive practice. But the general effect of meditation training is of settling ever more fully into one’s own skin, and suffering less, rather than more there.

As I discussed in The End of Faith, I view most psychedelic experiences as potentially misleading. Psychedelics do not guarantee wisdom. They merely guarantee more content. And visionary experiences, considered in their totality, appear to me to be ethically neutral. Therefore, it seems that psychedelic ecstasy must be steered toward our personal and collective well-being by some other principle. As Daniel Pinchbeck pointed out in his highly entertaining book, Breaking Open the Head, the fact that both the Mayans and the Aztecs used psychedelics, while being enthusiastic practitioners of human sacrifice, makes any idealistic link between plant-based shamanism and an enlightened society seem terribly naive.

As I will discuss in future essays, the form of transcendence that appears to link directly to ethical behavior and human well-being is the transcendence of egoity in the midst of ordinary waking consciousness. It is by ceasing to cling to the contents of consciousness—to our thoughts, moods, desires, etc.—that we make progress. Such a project does not, in principle, require that we experience more contents.[5]  The freedom from self that is both the goal and foundation of “spiritual” life is coincident with normal perception and cognition—though, admittedly, this can be difficult to realize.

The power of psychedelics, however, is that they often reveal, in the span of a few hours, depths of awe and understanding that can otherwise elude us for a lifetime. As is often the case, William James said it about as well as words permit[6] :

One conclusion was forced upon my mind at that time, and my impression of its truth has ever since remained unshaken. It is that our normal waking consciousness, rational consciousness as we call it, is but one special type of consciousness, whilst all about it, parted from it by the filmiest of screens, there lie potential forms of consciousness entirely different. We may go through life without suspecting their existence; but apply the requisite stimulus, and at a touch they are there in all their completeness, definite types of mentality which probably somewhere have their field of application and adaptation. No account of the universe in its totality can be final which leaves these other forms of consciousness quite disregarded. How to regard them is the question,—for they are so discontinuous with ordinary consciousness. Yet they may determine attitudes though they cannot furnish formulas, and open a region though they fail to give a map. At any rate, they forbid a premature closing of our accounts with reality.

(The Varieties of Religious Experience, p. 388)

 


NOTES:

  1. A wide literature now suggests that MDMA damages serotonin-producing neurons and decreases levels of serotonin in the brain. Here is the tip of the iceberg: 1, 2, 3, 4, 5, and 6.
  2. What is moderation? Let’s just say that I’ve never met a person who smokes marijuana every day who I thought wouldn’t benefit from smoking less (and I’ve never met someone who has never tried it who I thought wouldn’t benefit from smoking more).
  3. Physicalism, by contrast, could be easily falsified. If science ever established the existence of ghosts, or reincarnation, or any other phenomenon which would place the human mind (in whole or in part) outside the brain, physicalism would be dead. The fact that dualists can never say what would count as evidence against their views makes this ancient philosophical position very difficult to distinguish from religious faith.
  4. Terence McKenna is one person I regret not getting to know. Unfortunately, he died from brain cancer in 2000, at the age of 53. His books are well worth reading, and I have recommended several below, but he was, above all, an amazing speaker. It is true that his eloquence often led him to adopt positions which can only be described (charitably) as “wacky,” but the man was undeniably brilliant and always worth listening to.
  5. I should say, however, that there are psychedelic experiences that I have not had, which appear to deliver a different message. Rather than being states in which the boundaries of the self are dissolved, some people have experiences in which the self (in some form) appears to be transported elsewhere. This phenomenon is very common with the drug DMT, and it can lead its initiates to some very startling conclusions about the nature of reality. More than anyone else, Terence McKenna was influential in bringing the phenomenology of DMT into prominence.DMT is unique among psychedelics for a several reasons. Everyone who has tried it seems to agree that it is the most potent hallucinogen available (not in terms of the quantity needed for an effective dose, but in terms of its effects). It is also, paradoxically, the shortest acting. While the effects of LSD can last ten hours, the DMT trance dawns in less than a minute and subsides in ten. One reason for such steep pharmacokinetics seems to be that this compound already exists inside the human brain, and it is readily metabolized by monoaminoxidase. DMT is in the same chemical class as psilocybin and the neurotransmitter serotonin (but, in addition to having an affinity for 5-HT2Areceptors, it has been shown to bind to the sigma-1 receptor and modulate Na+ channels). Its function in the human body remains mysterious. Among the many mysteries and insults presented by DMT, it offers a final mockery of our drug laws: Not only have we criminalized naturally occurring substances, like cannabis; we have criminalized one of our own neurotransmitters.Many users of DMT report being thrust under its influence into an adjacent reality where they are met by alien beings who appear intent upon sharing information and demonstrating the use of inscrutable technologies. The convergence of hundreds of such reports, many from first-time users of the drug who have not been told what to expect, is certainly interesting. It is also worth noting these accounts are almost entirely free of religious imagery. One appears far more likely to meet extraterrestrials or elves on DMT than traditional saints or angels. As I have not tried DMT, and have not had an experience of the sort that its users describe, I don’t know what to make of any of this.
  6. Of course, James was reporting his experiences with nitrous oxide, which is an anesthetic. Other anesthetics, like ketamine hydrochloride and phencyclidine hydrochloride (PCP), have similar effects on mood and cognition at low doses. However, there are many differences between these drugs and classic psychedelics—one being that high doses of the latter do not lead to general anesthesia.

 

Recommended Reading:

Huxley, A. The Doors of Perception and Heaven and Hell.

McKenna, T. Food of the Gods: The Search for the Original Tree of Knowledge A Radical History of Plants, Drugs, and Human Evolution.

McKenna, T. The Archaic Revival: Speculations on Psychedelic Mushrooms, the Amazon, Virtual Reality, UFOs, Evolution, Shamanism, the Rebirth of the Goddess, and the End of History.

McKenna, T. True Hallucinations: Being an Account of the Author’s Extraordinary Adventures in the Devil’s Paradise.

Pinchbeck, D. Breaking Open the Head: A Psychedelic Journey into the Heart of Contemporary Shamanism.

Stevens, J. Storming Heaven: LSD and the American Dream.

Ratsch, C. The Encyclopedia of Psychoactive Plants: Ethnopharmacology and Its Applications.

Ott, J. Pharmacotheon: Entheogenic Drugs, Their Plant Sources and History.

Strassman, R. DMT: The Spirit Molecule: A Doctor’s Revolutionary Research into the Biology of Near-Death and Mystical Experiences.
Related article: What’s the Point of Transcendence?

via SamHarris.org

Magic Mushrooms Could Have Medical Benefits, Researchers Say

Magic Mushrooms Could Have Medical Benefits, Researchers Say

The hallucinogen in magic mushrooms may no longer just be for hippies seeking a trippy high.

Researchers at Johns Hopkins University School of Medicine have been studying the effects of psilocybin, a chemical found in some psychedelic mushrooms, that’s credited with inducing transcendental states. Now, they say, they’ve zeroed in on the perfect dosage level to produce transformative mystical and spiritual experiences that offer long-lasting life-changing benefits, while carrying little risk of negative reactions.

The breakthrough could speed the day when doctors use psilocybin–long viewed skeptically for its association with 1960s countercultural thrill-seekers–for a range of valuable clinical functions, like easing the anxiety of terminally ill patients, treating depression and post-traumatic stress disorder, and helping smokers quit. Already, studies in which depressed cancer patients were given the drug have reported positive results. “I’m not afraid to die anymore” one participant told The Lookout.

The Johns Hopkins study–whose results will be published this week in the journal Psychopharmacology–involved giving healthy volunteers varying doses of psilocybin in a controlled and supportive setting, over four separate sessions. Looking back more than a year later, 94 percent of participants rated it as one of the top five most spiritually significant experiences of their lifetimes.

More important, 89 percent reported lasting, positive changes in their behavior–better relationships with others, for instance, or increased care for their own mental and physical well-being. Those assessments were corroborated by family members and others.

“I think my heart is more open to all interactions with other people,” one volunteer reported in a questionnaire given to participants 14-months after their session.

“I feel that I relate better in my marriage,” wrote another. “There is more empathy — a greater understanding of people, and understanding their difficulties, and less judgment.”

Identifying the exact right dosage for hallucinogenic drugs is crucial, Roland Griffiths, a professor of psychiatry at Johns Hopkins who led the study, explained to The Lookout. That’s because a “bad trip” can trigger hazardous, self-destructive behavior, but low doses don’t produce the kind of transformative experiences that can offer long-term benefits. By trying a range of doses, Griffiths said, researchers were able to find the sweet spot, “where a high or intermediate dose can produce, fairly reliably, these mystical experiences, with very low probability of a significant fear reaction.”

In the 1950s and ’60s, scientists became interested in the potential effects of hallucinogens like psilocybin, mescaline, and lysergic acid diethylamide (LSD) on both healthy and terminally ill people. Mexican Indians had, since ancient times, used psychedelic mushrooms with similar chemical structures to achieve intense spiritual experiences. But by the mid ’60s, counterculture gurus like Dr. Timothy Leary and Aldous Huxley were talking up mind-altering drugs as a way of expanding one’s consciousness and rejecting mainstream society. Stories, perhaps apocryphal, circulated about people jumping out of windows while on LSD, and some heavy users were said to have suffered permanent psychological damage. By the early ’70s, the US government had essentially banned all hallucinogenic drugs.

But recent years have seen the beginning of a revival of mainstream scientific interest in mind-altering drugs, and particularly in the possibility of using them in a clinical setting to alleviate depression and anxiety. A 2004 study by the government of Holland (pdf) found psilocybin to have no significant negative effects.

Here in the United States, too, the climate may be shifting. In a statement accompanying the announcement of the Johns Hopkins findings, Jerome Jaffe, a former White House drug czar now at the University of Maryland School of Medicine, said the results raise the question of whether psilocybin could prove useful “in dealing with the psychological distress experienced by some terminal patients?”

The hope is that the long-lasting spiritual and transcendental experiences associated with psilocybin could–if conducted in a controlled and supportive setting, and with appropriate dosage levels–help ease patients’ fear and anxiety, allowing them to approach death with a greater sense of calm. (You can see one terminally ill cancer patient speak movingly about the positive effects of psilocybin here.)

Griffiths thinks the drug may have the potential to alleviate the suffering of terminal patients. He’s currently leading a separate Johns Hopkins psilocybin study, using volunteers who are depressed after being diagnosed with cancer. “So far we’ve had–anecdotally only–very positive results,” comparable to the study with healthy volunteers, he said. A study from the University of California, Los Angeles last year reported similar positive results.

But Griffiths said his study, under way for three years, has only recruited 20 patients, in part because oncologists are more interested in curing cancer than helping patients cope with its effects, so they don’t refer provide many referrals. “Most oncologists just don’t get it,” he said. “It’s not the focus of their research, and they’re busy people.”

But the experience of one volunteer in Griffiths’s study offers a glimpse of the potential benefits. Lauri Reamer, 47, told The Lookout that she participated in two Johns Hopkins psilocybin sessions last September, not long after ending intensive chemotherapy and radiation to treat a rare form of leukemia that, several times in the preceding few years, had almost taken her life.

Reamer, an anesthesiologist from Ruxton, Md., with three young daughters, said that although her disease was in remission by that time, she was still suffering psychologically from the trauma of the illness and the treatment. She had walled herself off emotionally, she said, and was unable to show empathy for others or even for herself.

The psilocybin had an immediate impact. “At the end of the session, I was just in this joyous, happy, relaxed state,” she said. “The drug was gone–what was left was just this peaceful calm.”

That calm had lasting benefits. Reamer said the experience–what she called “an epiphany”–gave her the impetus to get out of a failing marriage. Since doing so, she said, both she and her daughters have been much happier.

“I don’t think it was the drug that did it,” she said. “It was the drug that helped me find the clarity.”

That’s not the only improvement. “My sleeping has gotten better. My relationships have gotten better with people,” she said. “The fog has lifted.”

“The best thing it did for me was heal me psychologically and emotionally and allow me to be back in my kids’ lives, be back to being a mother,” Reamer concluded. As she spoke, she was taking her daughters–two 15-year old twins, and a 6-year-old–on a trip to Hershey Park.

And although doctors tell her that, thanks to the effect of the illness and the treatment, she likely has only 10 or 15 years to live, she’s able to approach that challenge with equanimity.

“My fear of death kind of disappeared,” she said. “I’m not afraid to die anymore.”

Griffiths, of Johns Hopkins, said Reamer’s experience isn’t an outlier among the volunteers, both sick and healthy, who have tried psilocybin. “People feel uplifted, and very often have a sense that everything is O.K. at one level,” he said. “That there’s sense to be made out of the chaos.”

“When you see people undergoing that kind of transformation,” he added, “it’s really quite moving.”

(Magic mushrooms at a farm in Hazerswoude, Netherlands, August, 2007: AP Photo/Peter Dejong)


via YahooNews

Magic Mushrooms Could Treat Depression

Magic Mushrooms Could Treat Depression

THE GIST
  • Psilocybin, the active ingredient in hallucinogenic mushrooms, shuts down parts of the brain that are responsible for regulating a sense of self.
  • In controlled settings, the drug may be a useful therapeutic tool for treating depression, anxiety and other psychiatric problems.
  • In the study, the rush of the first 10 to 30 seconds induced some fear, he added, but positive feelings then immediately swept over them.
After a psychedelic trip on magic mushrooms, people often describe the experience as mind-expanding, consciousness altering, emotionally insightful and even spiritually transcendent. Now, scientists have peered into the brains of people tripping on psilocybin — the active ingredient in mushrooms — and their results revealed a few surprises.

Instead of opening lines of communication between sensory-oriented regions of the brain, psilocybin appears to shut down activity in two key areas of the brain that regulate our sense of self and integrate our sense of awareness with our sense of the present.

PHOTOS: The Magic Mushrooms in My Yard

The drug also decreases activity in something called the default mode network, which is believed to be involved in maintaining a balanced sense of consciousness and ego through self-reflection, though scientists still don’t entirely understand the network or agree about what it does.

The more these brain areas were suppressed, the researchers report today in Proceedings of the National Academy of Sciences, the more intense people reported their changes in perception to be.

Besides helping explain how magic mushrooms induce hallucinogenic adventures of the mind, the results suggest that, in controlled settings, psilocybin might be a useful tool for treating depression and other psychiatric problems.

“One of the parts of the brain that is markedly switched off [with psilocybin] is the anterior cingulate cortex, which is particularly overactive in people with depression,” said David Nutt, professor of neuropsychopharmacology at Imperial College, London. Some researchers “put electrodes in that part of the brain to switch it off. It would be a lot simpler and safer to use psilocybin instead of electrodes.”

In British author Aldous Huxley’s ruminations on the effects of mescaline, a psychedelic compound that occurs naturally in the Peyote cactus, he expressed the sense that the hallucinogenic drug removed natural constraints that keep the brain focused on the inputs and tasks necessary for normal functioning. By removing those constraints, Huxley speculated, hallucinogenic drugs create an otherworldly sense of reality and a mystical state of transcendence and transformation.

From subjective descriptions like those, scientists have long assumed that hallucinogens, like mescaline and psilocybin, work in the brain by increasing blood flow and creating new kinds of connections. Research on psychedelic effects in the brain, however, has been limited and hard to get approval for.

For the new study, Nutt and colleagues recruited 15 healthy people with previous experience taking hallucinogenic substances. Over two days, the researchers monitored activity in participants’ brains as they lay in a scanner for up to an hour. On the first day, participants received an intravenous shot of a placebo solution. The next day, they got a shot of psilocybin that was dosed to peak after about four minutes and was mostly over after about 30 minutes.

No one had trouble figuring out which shot contained the real drug. Afterwards, they talked at length about their experiences.

NEWS: Brain Waves Surge Moments Before Death

All of the participants described kaleidoscopic vision with images of bright and angular shapes, Nutt said. The rush of the first 10 to 30 seconds induced some fear, he added, but positive feelings then immediately swept over them. Many participants said that the benefits of the experience were profound and that they felt they had moved on from where they had been. Others said the experience was interesting, though not necessarily life-changing. None described the trip as negative.

“They mostly got the sense that they were going somewhere else, that they were being transmuted into space and being fragmented or stretched,” Nutt said. “One guy found himself kneeling at the feet of God. Some described being at one with the universe.”

In brain scans, the researchers saw a decrease in both blood flow and metabolism in several key areas after injection with the drug, including the anterior cingulate cortex, the medial prefrontal cortex and the posterior cingulate cortex. Also reduced was connectivity and communication between some of these areas.

The findings offer some potentially exciting opportunities to use psilocybin in therapeutic settings, said Roland Griffiths, a neuroscientist and pscyhopharmacologist at Johns Hopkins University in Baltimore.

His research has shown some long-lasting cognitive benefits of psilocybin, with study subjects reporting that they feel happier, calmer and more at peace more than a year after taking a carefully measured dose of the drug in an experimental setting. He is currently conducting a trial with cancer patients who are anxious or depressed.

Nutt plans next to see if the hallucinogen, combined with therapy, might be able to help calm hyperactive brain regions in people with enduring depression who are locked into obsessively negative mindsets.

NEWS: Ancient Mayans Enjoyed Hallucinogens

There is reason to believe it might work. In another study, also published today in The British Journal of Psychiatry, Nutt and colleagues report that guiding people to think positively about events in their past while they were under the influence of psilocybin led to a greater sense of well-being two weeks later.

While the research offers tantalizing evidence that psilocybin can be safe and helpful in clinical settings, Griffiths said, the hallucinogen still carries risks when people take it on their own. Depending on the dose and the situation, the drug can lead to panic and cause people to harm themselves or others.

“From a cultural point of view, there may be some applications that are useful and therapeutic,” Griffiths said. “But I’m not sure we’re ever going to be able to go to the drug store, pick it up and bring it home.”

SOURCE:
http://news.discovery.com/human/magic-mushrooms-depression-122301.html

By: Emily Sohn, January 23, 2012