Many have suggested that Seth McFarlane might be hinting at hidden truths in his various shows on Fox.
Here are just a few of the topics covered in the past (not the full list, yet)
The cure for cancer being hidden by corporations (Family Guy)
Aliens working with the CIA/Gov (American Dad)
Mind Control by Technology (American Dad)
Boston Bombing ‘Coincidence’ (Family Guy)
Robin Williams Suicide ‘Coincidence’ (Family Guy)